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Transcription factor 7-like 2 (TCF7L2) Gene Polymorphism rs7903146 is Associated with Lipid Profile and Risk of Cardiovascular Disease in Metabolic Syndrome Subjects


Author(s): Mahnaz Rezaei, Abbasali Palizban, Setare Zamani-doabi, Maryam Shojaee

"Transcription factor 7-like 2 (TCF7L2) polymorphisms especially rs7903146(C/T) are related to type 2 diabetes (T2D) and other metabolic diseases; Metabolic Syndrome(MetS), atherosclerosis and cardiovascular disease (CVD) risk, this study is performed in order to evaluate the relationship between TCF7L2 polymorphism rs7903146 to Metabolic Syndrome (MetS) and CVD risk. Blood samples were collected from the MetS (n=92) and control (n=80) subjects. The subjects were characterized according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III). Blood DNA was extracted and genotyped by mismatch PCR-RFLP. A logistic regression model was performed to analyze the data. T-TEST and ANOVA (Analysis Of Variance) were used to compare differences between CC and CT+TT rs7903146 genotypes. The biochemical factors showed that BMI, SBP, DBP, FBS, TG levels in the MetS subjects were meaningfully higher than Normal subjects (P=0.001, P=0.000, P=0.000, P=0.031, P=0.000) and HDL level in the MetS subjects was Lower than Normal subjects (P=0.003). The biochemical factors and genotype analysis indicated that FBS and TG levels in the CT+ TT genotypes were significantly higher than that of CC genotype in MetS subjects (P =0.000); The HDL level and BMI in CC genotype were higher (P=0.003, P=0.002). Furthermore, logistic regression analysis of the genotype frequencies for people with a history of cardiovascular disease and people without cardiovascular disease in metabolic syndrome subjects, showed that the odds ratios (OR) of CT+ TT genotypes carriers for CVD risk were higher than those of CC genotypes carriers (OR: 2.8889; 95 % CI : 1.0344 - 8.0680; P = 0.0429). There was relative risk for CT+ TT genotypes versus CC genotype (RR: 1.3542; 95 % CI: 1.0386 - 1.7656; P = 0.0251). Results of this study revealed that the CT+ TT genotypes carriers rs7903146 variation could be predisposed to CVD risk."

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