Journal of Biology and Today's World

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"Protein oxidation biomarker (SH- group) in plasma of Rheumatoid Arthritis"


Author(s): Javad Zavar-Reza, Hamidreza Shahmoradi, Davoud Javidmehr, Hamidreza Yousefi, Fereshte Ahmadian, Ali Dehghani, Ali Dehghan, Mohammad Hossein Azaraein, Tahere Barabadi

"Rheumatoid Arthritis is the most common inflammatory disease of the joints. Approximately 1-2% of the general population worldwide suffers from Rheumatoid Arthritis. It is a chronic and progressive autoimmune disease in which joints are involved symmetrically; it is often accompanied by pain and fatigue. In this study, SH - group in patients with Rheumatoid Arthritis and healthy individuals has been observed. Around 30 Rheumatoid Arthritis patients and 30 healthy individuals as control subjects selected as control group. Five cc Heparin blood was taken from patients and the SH- group test was executed. This test depicts the level of oxidative stress. SH - group level was not significantly higher (P = 0.577) in healthy individuals compared to Rheumatoid Arthritis patients. Oxidation of Group SH - group is an indicator of stress, which is called thiol oxidation of proteins. Oxidative stress can influence the oxidation of proteins. Oxidative stress caused by free radicals is involved for resonance and can affect the thiol groups, which may cause damage to tissues."

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