Journal of Biology and Today's World

"Prevalence of cagA and babA2 genes in Helicobacter Pylori strains Isolated from Iranian gastrointestinal disorder patients and their gastritis classification"

Abstract

Author(s): Heshmat Shahi, Somayeh Reiis, Marzieh Sadeghiani, Majid Mahsa, Rasol Bahreini, Mandana Moghni, Mohamad-sadegh damavandi, Fereshte fatollahi, Elahe Shahverdi, Ghasem ramezani, Hedayatollah Shirzad

"Helicobacter pylori is a spiral gram negative flagellate bacteria and localize in the stomach. H.p infection is a worldwide health problem and identified as an important cause of gastritis and gastric cancer and its ability to develop such disorders is related to its virulence factors and environment. cagA is the most important Hp virulence factor that directly penetrate into gastric epithelial cells by bacterial secretion system (T4SS) from pathogenicity island (PAI) and disrupts cell homeostasis. Adherence factors are significant for bacterial colonization and suitable function of other virulence factor. Blood group antigen binding adhesion (babA) is an outer membrane protein (OMP) that binds to ABO blood group antigen and can stimulate inflammatory response in gastric cells. Our main target was to determine the roles and prevalence of cagA and babA2 virulence factor in gastrointestinal disorders in Iranian patients. Existences of These factors were determined by PCR in 218 patients with gastrointestinal disorders. Semi-quantitative methods of scoring according to the Updated Sydney classification system were used for detection of H.pylori density, neutrophil and monocyte cells infiltration. A high prevalence of cagA positive (81.4%) and babA2 positive (35%) were found. The most combined genotype (cagA&babA2) prevalence was found in gastritis & ulcer (100%) (P < 0.001). High prevalence of cagA positive observed in active inflammation phase 76.9% and high prevalence of babA2 positive was in active phase 61.1% of H.pylori gastritis (P=0.001) . Results of this study showed information about the high prevalence of cagA genes in H.pylori infected patients and their rolls in active gastrointestinal disorders."

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