Journal of Biology and Today's World

"Evaluation of Malondialdehyde (MDA) in type 2 diabetic Patients with Coronary Artery Disease (CAD)"

Abstract

Author(s): Javad Zavar-Reza, Hamidreza Shahmoradi, Alireza Mohammadyari, Maryam Mohammadbeigi, Rasoul Hosseini, Mahmoud Vakili, Tahere Barabad, Fahima DaneshPouya, Marjan Tajik-kord, Ehsan Shahmoradi

"In this study, we evaluate Malondialdehyde plasma in type two diabetic Patients with Coronary Artery Disease compared with type 2 diabetic patients. This case - control study was conducted using random sampling. Study was carried out on blood from samples of 30 type 2 diabetic patients and 30 diabetic patients with CAD of age and sex matched subjects. Heparinized blood samples were taken from the patients. The separated plasma was used for biochemical tests and lipid peroxidation. Malondialdehyde level were significantly (P = 0.000) higher in type 2 diabetic Patients with Coronary Artery Disease compared with type 2 diabetic patients. The significant difference in the increase of MDA in diabetic patients with CAD may play a significant role in the development of dangerous complications in these patients because increase in the Malondialdehyde levels and decrease in antioxidant defense system in the body can lead to cell damage."

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