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A Case/Control Study of Evaluating the Serum Levels of New Risk Factors for Cardiovascular Diseases in Iranian patients

Abstract

Author(s): Mohammad Reza Safari, Mir Davood Omrani, Sayyed Mohammad Hossein Ghaderian, Arezou Sayad, Mohammad Taheri

Early diagnosis is the cornerstone of cardiovascular diseases management. In this study the predictive value of N-Terminal Probrain Natriuretic Peptide(NT-proBNP), High-Sensitivity Cardiac Troponin T (hs-cTnT), Myeloperoxidase (MPO) and Pregnancy-Associated Plasma Protein A (PAPP-A) were investigated in Iranian Acute Myocardial Infarction (AMI) patients, Unstable Angina (UA) patients, Coronary Artery Disease (CAD) patients and normal subjects . The present study was performed on 35 AMI patients, 35 UA patients, 35 CAD patients and 53 healthy individuals. NT-proBNP, hs-cTnT, MPO and PAPP-A were quantitated by ELISA kits. The cardiovascular patients had significantly higher levels of NT-proBNP, hs-cTnT, MPO and PAPP-A (p<0.05) as compared with normal individuals. The obtained results indicated that the serum levels of NT-proBNP, hs-cTnT, MPO and PAPP-A significantly increased in cardiovascular patients and would be strongly predictive in these diseases.

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